anazima

The antibody, BIIB033, a fully human anti-LINGO-1 monoclonal antibody blocking epitopes in the LINGO-1 immunoglobulin G domain, is currently under study for MS [Tran et al. 2014]. Undifferentiated oligodendrocytes express LINGO-1 and its upregulation after an acute demyelinating attack may interfere with oligodendrocyte differentiation and subsequent remyelination. Phase I studies found that BIIB033 is safe … Read more